What is one of the main effects of meth that can persist after acute use?

Severe depression is one of the main effects of methamphetamine use that can persist even after the acute effects of the drug have worn off. This phenomenon is often linked to the significant alterations that meth causes in the brain's chemistry, particularly regarding neurotransmitters such as dopamine. During its use, meth releases high levels of dopamine, which can lead to the euphoric feelings commonly associated with the drug. However, this surge in dopamine can lead to a depletion of the neurotransmitter after the drug is metabolized, resulting in feelings of depression or an "emotional crash." This post-use depression can be profound and may last for days or even weeks.

Acknowledging this factor is crucial for understanding the broader context of methamphetamine addiction and its long-term consequences on mental health. This underscores the importance of recognizing the signs of withdrawal, which often includes severe mood disturbances, as part of the recovery process for individuals who have used meth.