What are some potential health effects of long-term use of controlled substances?

Long-term use of controlled substances can lead to significant and often severe health effects. Addiction is a primary concern, as substances that are classified as controlled can create a physical or psychological dependence. This means the individual may find it increasingly challenging to stop using the substance, often leading to a cycle of abuse.

Additionally, mental health disorders can arise from prolonged use, including anxiety, depression, and psychosis. These conditions can be exacerbated by the effects of the substances themselves, as well as by the lifestyle changes that often accompany addiction.

Chronic health issues are also a major risk; sustained abuse of controlled substances can lead to various physical ailments. For instance, the cardiovascular system can be significantly impacted, and liver or kidney function may deteriorate depending on the substance and its effects on the body.

This understanding emphasizes the profound impact of controlled substances on both mental and physical health when used over extended periods, aligning with the selected answer.